研究项目：

1.“丁酸及产丁酸菌在维持肠道稳态及重症胰腺炎中的作用研究”，国自然科学基金面上项目，主持，2019.01-2022.12

2.“自身免疫型糖尿病中肠源抗菌肽的功能研究“，江苏省自然科学基金杰出青年项目，2020-2012

3.“针对胰腺健康的酪酸梭菌研究开发”，江苏省双创计划团队项目，2019.01-2021.12

4.“抗菌肽cathelicidins在维持肠道免疫稳态及1型糖尿病发病中的作用研究”，国家自然科学基金重大研究计划（培育项目），主持，2017.01-2019.12

5.“肠道丁酸在1型糖尿病免疫炎症中作用及分子机制研究”,国家自然科学基金面上项目，主持，2016.01-2019.12

6.“短链脂肪酸调控胰肠区域免疫稳态及机理研究”,中央高校专项自主科研项目-重点项目（A类），主持，项目号JUSRP51613A，2016.01-2018.12

7.“功能脂肪酸与抗菌肽的健康机理与药食应用研究”,启动基金，主持，2015.01-2017.12

8.“抗菌肽的天然诱导剂筛选”，国家高端外国专家项目，中方负责人，2014.01-2015.12

9.“抗菌肽cathelicidins对beta细胞功能的免疫调节作用及机理研究”，国家自然科学基金青年项目，主持，2015.01-2017.12

10.“功能活性物质的内源诱导对宿主免疫防御与慢性病防治的影响及相关新型营养产品的开发”，江苏省双创计划人才项目，主持，2015.01-2017.12

11.“新型抗糖尿病胰岛炎症的免疫防御肽内源诱导剂的开发”，江苏省六大人才高峰项目，主持，2015.91-2017.12

12.“膳食脂肪与宿主防御肽在胰腺beta细胞功能和糖尿病预防重的作用与机制研究”，江苏省自然科学基金青年项目，主持，2014.01-2016.12

►代表性文章

[1]Sun, J., Furio, L., Mecheri, R., van der Does, A. M., Lundeberg, E., Saveanu, L., Chen, Y., van Endert, P., Agerberth, B., & Diana, J. (2015). Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota.Immunity, 43(2), 304–317. https://doi.org/10.1016/j.immuni.2015.07.013(IF:32.4，封面文章)

[2]Liang, W., Enée, E., Andre-Vallee, C., Falcone, M.,Sun, J*., & Diana, J*. (2022). Intestinal Cathelicidin Antimicrobial Peptide Shapes a Protective Neonatal Gut Microbiota Against Pancreatic Autoimmunity.Gastroenterology, 162(4), 1288–1302.e16. https://doi.org/10.1053/j.gastro.2021.12.272(IF:29.4)

[3]Pan, L. L., Ren, Z. N., Yang, J., Li, B. B., Huang, Y. W., Song, D. X., Li, X., Xu, J. J., Bhatia, M., Zou, D. W., Zhou, C. H., &Sun, J*. (2023). Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram-positive bacteria.ActaPharmaceutica Sinica B, 13(10), 4202–4216. https://doi.org/10.1016/j.apsb.2023.08.002(IF:14.5，封面文章)

[4]Pan, X., Zhu, Q., Pan, L. L., &Sun, J*. (2022). Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy.Pharmacology &Therapeutics, 238, 108176. https://doi.org/10.1016/j.pharmthera.2022.108176(IF:13.5)

[5]Jia, L., Li, J., Zhang, M., Liu, H., Ren, Z., Dong, X. L., Pan, X., Qiu, J., Pan, L. L., &Sun, J*. (2022). Cathelicidin-related antimicrobial peptide protects against enteric pathogen-accelerated type 1 diabetes in mice.Theranostics, 12(7), 3438–3455. https://doi.org/10.7150/thno.61433(IF:12.4)

[6]Pan, L. L., Ren, Z., Tu, X., Liu, H., Tay, H. L., Li, J., Pan, X., Dong, X., Foster, P. S., &Sun, J*. (2021). GPR109A deficiency promotes IL-33 overproduction and type 2 immune response in food allergy in mice.Allergy, 76(8), 2613–2616. https://doi.org/10.1111/all.14849(IF:12.4)

[7]Ren, Z., Pan, L. L., Huang, Y., Chen, H., Liu, Y., Liu, H., Tu, X., Liu, Y., Li, B., Dong, X., Pan, X., Li, H., Fu, Y. V., Agerberth, B., Diana, J*., &Sun, J*. (2021). Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy.EMBOMolecularMedicine, 13(8), e14059. https://doi.org/10.15252/emmm.202114059(IF:11.1，封面文章)

[8]Liu, H., Dong, X., Jia, K., Yuan, B., Ren, Z., Pan, X., Wu, J., Li, J., Zhou, J., Wang, R. X., Qu, L.,Sun, J*., & Pan, L. L*. (2023). Protein arginine methyltransferase 5-mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formation.CardiovascularResearch, 119(11), 2142–2156. https://doi.org/10.1093/cvr/cvad080(IF:10.9)

[9]Li, B., Pan, L. L., Pan, X., Dong, X., Ren, Z., Zhang, H., Chen, W., de Vos, P., &Sun, J*. (2024). Opportunities and challenges of polyphenols and polysaccharides for type 1 diabetes intervention.CriticalReviews inFoodScience andNutrition, 64(10), 2811–2823. https://doi.org/10.1080/10408398.2022.2126962(IF:10.2)

[10]Ren, Z., Pan, X., Li, J., Dong, X., Tu, X., Pan, L. L., &Sun, J*. (2023). G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.PharmacologicalResearch, 191, 106754. https://doi.org/10.1016/j.phrs.2023.106754(IF:9.3)

[11]Pan, X., Li, J., Tu, X., Wu, C., Liu, H., Luo, Y., Dong, X., Li, X., Pan, L. L., &Sun, J*. (2020). Lysine-specific demethylase-1 regulates fibroblast activation in pulmonary fibrosis via TGF-β1/Smad3 pathway.PharmacologicalResearch, 152, 104592. https://doi.org/10.1016/j.phrs.2019.104592(IF:9.3)

[12]Bei, Y., Pan, L. L., Zhou, Q., Zhao, C., Xie, Y., Wu, C., Meng, X., Gu, H., Xu, J., Zhou, L., Sluijter, J. P. G., Das, S., Agerberth, B.,Sun, J*., & Xiao, J*. (2019). Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.BMCMedicine, 17(1), 42. https://doi.org/10.1186/s12916-019-1268-y(IF:9.3)

[13]Liu, H., Jia, K., Ren, Z.,Sun, J*., & Pan, L. L*. (2022). PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells.CellDeath &Disease, 13(4), 299. https://doi.org/10.1038/s41419-022-04719-7(IF:9.0)

[14]Pan, L. L., Li, B. B., Pan, X. H., &Sun, J*. (2021). Gut microbiota in pancreatic diseases: possible new therapeutic strategies.ActaPharmacologica Sinica, 42(7), 1027–1039. https://doi.org/10.1038/s41401-020-00532-0(IF:8.2，封面文章)

[15]Ren, Z. N., Yang, J., Zhang, M. Y., Huang, Y. W., Song, D. X., Sun, X., Pan, L. L*., &Sun, J*. (2022). A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis.ActaPharmacologica Sinica, 43(5), 1264–1273. https://doi.org/10.1038/s41401-021-00744-y(IF:8.2)

[16]Li, J., Pan, X., Ren, Z., Li, B., Liu, H., Wu, C., Dong, X., de Vos, P., Pan, L. L*., &Sun, J*. (2022). Protein arginine methyltransferase 2 (PRMT2) promotes dextran sulfate sodium-induced colitis by inhibiting the SOCS3 promoter via histone H3R8 asymmetric dimethylation.BritishJournal ofPharmacology, 179(1), 141–158. https://doi.org/10.1111/bph.15695(IF:7.3)

[17]Pan, X., Fang, X., Wang, F., Li, H., Niu, W., Liang, W., Wu, C., Li, J., Tu, X., Pan, L. L*., &Sun, J*. (2019). Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.BritishJournal ofPharmacology, 176(23), 4446–4461. https://doi.org/10.1111/bph.14806(IF:7.3)

[18]Pan, L. L., Liang, W., Ren, Z., Li, C., Chen, Y., Niu, W., Fang, X., Liu, Y., Zhang, M., Diana, J., Agerberth, B., &Sun, J*. (2020). Cathelicidin-related antimicrobial peptide protects against ischaemia reperfusion-induced acute kidney injury in mice.BritishJournal ofPharmacology, 177(12), 2726–2742. https://doi.org/10.1111/bph.14998(IF:7.3)

[19]Tian, H., Li, J., Chen, X., Ren, Z., Pan, X., Huang, W., Bhatia, M., Pan, L. L*., &Sun, J*. (2023). Oral Delivery of Mouse β-Defensin 14 (mBD14)-Producing Lactococcus lactis NZ9000 Attenuates Experimental Colitis in Mice.Journal ofAgricultural andFoodChemistry, 71(13), 5185–5194. https://doi.org/10.1021/acs.jafc.2c07098(IF:6.1)

[20]Zhang, Z., Li, J., Zhang, M., Li, B., Pan, X., Dong, X., Pan, L. L*., &Sun, J*. (2022). GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.MolecularNutrition &FoodResearch, 66(23), e2200300. https://doi.org/10.1002/mnfr.202200300(IF:5.2)

奖励

[1]江苏省双创团队领军人才，排名1

[2]科学中国人年度杰出青年科学家提名

[3]江苏省科协第六届优秀学术论文奖（二等奖），排名1

[4]益海嘉里金龙鱼青年教师奖，排名1

[5]江苏省双创计划人才，排名1

[6]“国家级引进人才”入选者(青年)

[7]瑞典Rolf Luft Fellowship，Rolf Luft糖尿病研究基金会研究奖，排名1（当年唯一）

[8]瑞典CERIC Fellowship，瑞典心血管与炎症卓越中心CERIC研究奖，排名1

[9]江苏省药理科学技术奖一等奖，排名1